Generation of induced pluripotent stem cells from renal tubular cells of a patient with Alport syndrome.

Generation of induced pluripotent stem cells from renal tubular cells of a patient with Alport syndrome.

Alport syndrome (AS) is a hereditary disease that leads to kidney failure and is caused by mutations in the COL4A3, COL4A4, and COL4A5 genes that lead to the absence of collagen α3α4α5 (IV) networks in the mature kidney glomerular basement membrane. Approximately 80% of AS is X-linked because of mutations in COL4A5, the gene encoding the alpha 5 chain of type IV collagen.

To investigate the pathogenesis of AS at the genetic level, we generated induced pluripotent stem cells (iPSCs) from renal tubular cells of a patient with AS. The successful iPSC generation laid the foundation to master the repair of the COL4A5 gene and to evaluate the differentiation of iPSC into Sertoli cells and the accompanying epigenetic changes at each stage. The generation of iPSCs from AS patients not only confirms that iPSCs could be generated from renal tubular cells, but also provides a novel type of genetic therapy for AS patients. In this study, we generated iPSCs from renal tubular cells via ectopic expression of four transcription factors (Oct4, Sox2, c-myc, and Klf4).

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Mouse antibody for Gram + bacteria LTA

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Description: This is purified Mouse monoclonal antibody against Gram + bacteria LTA for WB, ELISA.

Mouse antibody for Gram + bacteria LTA

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Gram + bacteria

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Mouse antibody for Neisseria gonorrhoeae intact bacteria

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Description: This is purified Mouse monoclonal antibody against Neisseria gonorrhoeae intact bacteria for WB, ELISA.

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Description: This is purified Mouse monoclonal antibody against Neisseria gonorrhoeae intact bacteria for WB, ELISA.

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Bacteria Genomic DNA Kit

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Psychrophilic Bacteria Count Plate

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QPCR Kit DNA Bacteria DomaiMmix

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Necrotizing hepatopancreatitis bacteria

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Necrotizing hepatopancreatitis bacteria

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Anti-Gram-negative bacteria Endotoxin Monoclonal antibody, Clone 23-557.4

DMABT-Z60064 500 µg
EUR 945
Description: Mouse

Anti-Gram-negative bacteria Endotoxin Monoclonal antibody, Clone 23-334.6

DMABT-Z60333 500 µg
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Description: Mouse

Rapid Bacteria RNA Isolation Kit

BS8625 50Preps
EUR 95.63

Bacteria lysing CK01-15mL - PK25

HOM1096 PK25
EUR 257.85

Lactic Acid Bacteria Count Plate

KGR014 12tests
EUR 24
Description: Enrichment, 36℃±1℃,48±2h

Acid Fast Bacteria Control Slides

HCS1001-25 25 Slides
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12 Test System for Neg Bacteria

MIC6708 PK24
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Lysis Buffer for Bacteria, pH 8.0

22040068-1 500 mL
EUR 60.27

Lysis Buffer for Bacteria, pH 8.0

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Isolation Medium For Iron Bacteria

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EUR 14.77
Description: Isolation Medium For Iron Bacteria

Isolation Medium For Iron Bacteria

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EUR 43.27
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Acid Fast Bacteria (AFB) Stain Kit

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Acid Fast Bacteria (AFB) Stain Kit

FAB-2 30 ml ea.
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Acid Fast Bacteria (AFB) Stain Kit

FAB-500 500 ml ea.
EUR 146.57

Bacteria DNA Preparation - Column Kit

PP-214L 250preparations
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Bacteria DNA Preparation - Column Kit

PP-214S 50preparations
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*Lactic Acid Bacteria Selective Agar

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EUR 25.78
Description: *Lactic Acid Bacteria Selective Agar

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Description: *Lactic Acid Bacteria Selective Agar

Bacteria-Derived Collagenase Purified

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Description: Bacteria-Derived Collagenase Purified

Lipopolysaccharide (LPS gram negative bacteria) goat polyclonal antibody, Purified

BP2235 1 ml Ask for price

Bead Beating Tube Type A (Bacteria)

BB0108(C1BTA050) each
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Bacteria-Derived Deoxyribonucleic Acid

IBCTDNA10MG each
EUR 199
Description: Bacteria-Derived Deoxyribonucleic Acid

Counting Chamber Helber Bacteria - EACH

COU9100 EACH
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Bacteria DNA Preparation - Solution Kit

PP-206L 500preparations
EUR 315.5

Bacteria DNA Preparation - Solution Kit

PP-206S 100preparations
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Bacteria-Derived Diaphorase Lyophilized

IBCTDTLY1KU each
EUR 96
Description: Bacteria-Derived Diaphorase Lyophilized

Bacteria-Derived Diaphorase Lyophilized

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EUR 143
Description: Bacteria-Derived Diaphorase Lyophilized

genesig Easy kit for Bacteria Domain

Z-Path-Eubacteria-EASY 50 tests
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Description: Eubacteria

Lactic Bacteria Differential HiVeg Agar

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EUR 43.37
Description: Lactic Bacteria Differential HiVeg Agar

Geneaid™ DNA Isolation Kit (Bacteria)

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EUR 3

Geneaid™ DNA Isolation Kit (Bacteria)

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EUR 450

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Bacteria beta Galactosidase (GLB1) Protein

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EUR 41.3
Description: Lactic Bacteria Differential HiVeg Broth

Bacteria Genomic DNA Kit (No RNase A)

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EUR 276

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Ribo-off rRNA Depletion Kit (Bacteria)

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EUR 507.6

Ribo-off rRNA Depletion Kit (Bacteria)

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FastPure Bacteria DNA Isolation Mini Kit

DC103 100 rxn
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FastPure Bacteria DNA Isolation Mini Kit

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EUR 52

Rapid Bacteria Genomic DNA Isolation Kit

BS8225 50Preps
EUR 91.97

Bacteria-Derived ATG3 Recombinant Protein

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Description: Bacteria-Derived ATG3 Recombinant Protein

Bacteria-Derived GSTP1 Recombinant Protein

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Description: Bacteria-Derived GSTP1 Recombinant Protein

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EUR 18.59
Description: HiPurA® Food Pathogen (Bacteria) DNA Pur

HiPurA® Food Pathogen (Bacteria) DNA Pur

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EUR 41.81
Description: HiPurA® Food Pathogen (Bacteria) DNA Pur

Magnetic Beads DNA Extraction Kit (Bacteria)

ME004 each
EUR 3

Magnetic Beads DNA Extraction Kit (Bacteria)

ME048 each
EUR 60

Magnetic Beads DNA Extraction Kit (Bacteria)

ME096 each
EUR 110

EZ E1 (RNA-Be-Locked) Solution- Bacteria

RT91712 25ml
EUR 87.14

Ribo-off rRNA Depletion Kit V2 (Bacteria)

N417-01 12 rxns
EUR 275

Ribo-off rRNA Depletion Kit V2 (Bacteria)

N417-02 24 rxns
EUR 486

Petrifilm Lactic Acid Bacteria Plates - PK500

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EUR 1220.4

Bacteria-Derived Galactosidase Beta Purified

IBCTGLBB1KU each
EUR 121
Description: Bacteria-Derived Galactosidase Beta Purified

Bacteria-Derived Galactosidase Beta Purified

IBCTGLBB5KU each
EUR 493
Description: Bacteria-Derived Galactosidase Beta Purified

Genorise® Bacteria DNA Extraction Kit 1000

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EUR 1045

Genorise® Bacteria DNA Extraction Kit 500

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EUR 480

Genorise® Bacteria DNA Extraction Kit 200

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EUR 258

Genorise® Bacteria DNA Extraction Kit 100

GR101063 100
EUR 144

Genorise® Bacteria DNA Extraction Kit 50

GR101064 50
EUR 87

Geneaid™ DNA Isolation Kit (Bacteria) Plus

GEE1.5K-A each
EUR 480

Necrotizing hepatopancreatitis bacteria PCR kit

PCR-V281-48D 50T
EUR 543.6

Necrotizing hepatopancreatitis bacteria PCR kit

PCR-V281-96D 100T
EUR 686.4

Bacteria-Derived HO-1 Recombinant Protein

IBCTHMOX1R10UG each
EUR 312
Description: Bacteria-Derived HO-1 Recombinant Protein

Bacteria-Derived Alkaline Phosphatase Purified

IBCTALPPF10MG each
EUR 222
Description: Bacteria-Derived Alkaline Phosphatase Purified

Bacteria-Derived Alkaline Phosphatase Purified

IBCTALPPF5MG each
EUR 137
Description: Bacteria-Derived Alkaline Phosphatase Purified

Presto™ Mini gDNA Bacteria Kit (M-Grade)

GBB004 each
EUR 3

Presto™ Mini gDNA Bacteria Kit (M-Grade)

GBB100 each
EUR 108

Presto™ Mini gDNA Bacteria Kit (M-Grade)

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EUR 89

Presto™ Mini gDNA Bacteria Kit (M-Grade)

GBB300 each
EUR 291.5

Presto™ Mini gDNA Bacteria Kit (M-Grade)

GBB301 each
EUR 240

Prolysol BC Protein extraction buffer, Bacteria

P4100-100 100 rxns
EUR 271.2

Bacteria-Derived Collagenase Type 1 Purified

IBCTCLS1T100MG each
EUR 97
Description: Bacteria-Derived Collagenase Type 1 Purified

Bacteria-Derived Collagenase Type 2 Purified

IBCTCLS2T100MG each
EUR 97
Description: Bacteria-Derived Collagenase Type 2 Purified

Bacteria-Derived Collagenase Type 2 Purified

IBCTCLS2T1GM each
EUR 343
Description: Bacteria-Derived Collagenase Type 2 Purified

Bacteria-Derived Collagenase Type 2 Purified

IBCTCLS2T5GM each
EUR 1169
Description: Bacteria-Derived Collagenase Type 2 Purified

Bacteria-Derived Collagenase Type 3 Purified

IBCTCLS3T100MG each
EUR 97
Description: Bacteria-Derived Collagenase Type 3 Purified

Bacteria-Derived Collagenase Type 3 Purified

IBCTCLS3T1GM each
EUR 338
Description: Bacteria-Derived Collagenase Type 3 Purified

Bacteria-Derived Collagenase Type 3 Purified

IBCTCLS3T5GM each
EUR 1171
Description: Bacteria-Derived Collagenase Type 3 Purified

Bacteria-Derived Collagenase Type 4 Purified

IBCTCLS4T100MG each
EUR 97
Description: Bacteria-Derived Collagenase Type 4 Purified

Bacteria-Derived Collagenase Type 4 Purified

IBCTCLS4T1gm each
EUR 343
Description: Bacteria-Derived Collagenase Type 4 Purified

Bacteria-Derived Collagenase Type 4 Purified

IBCTCLS4T5gm each
EUR 1190
Description: Bacteria-Derived Collagenase Type 4 Purified

Bacteria-Derived Collagenase Type 5 Purified

IBCTCLS5T100MG each
EUR 97
Description: Bacteria-Derived Collagenase Type 5 Purified

Bacteria-Derived Collagenase Type 5 Purified

IBCTCLS5T1GM each
EUR 389
Description: Bacteria-Derived Collagenase Type 5 Purified

Bacteria-Derived Collagenase Type 5 Purified

IBCTCLS5T5GM each
EUR 1248
Description: Bacteria-Derived Collagenase Type 5 Purified

Bacteria-Derived Collagenase Type 6 Purified

IBCTCLS6T100MG each
EUR 101
Description: Bacteria-Derived Collagenase Type 6 Purified

Bacteria-Derived Collagenase Type 6 Purified

IBCTCLS6T500MG each
EUR 364
Description: Bacteria-Derived Collagenase Type 6 Purified

Bacteria-Derived Collagenase Type 7 Purified

IBCTCLS7T100MG each
EUR 109
Description: Bacteria-Derived Collagenase Type 7 Purified

Bacteria-Derived Collagenase Type 7 Purified

IBCTCLS7T2500MG each
EUR 990
Description: Bacteria-Derived Collagenase Type 7 Purified

Bacteria-Derived Collagenase Type 7 Purified

IBCTCLS7T500MG each
EUR 412
Description: Bacteria-Derived Collagenase Type 7 Purified

One-Tube Bacteria Genomic DNA Isolation Kit

BS8413 100preps
EUR 94.72

One-Tube Bacteria Genomic DNA Isolation Kit

BS8414 500Preps, 500prep
EUR 198.85

Bacteria-Derived Tryosine Decarboxylase APOenzyme

IBCTTYRAPO1GM each
EUR 341
Description: Bacteria-Derived Tryosine Decarboxylase APOenzyme

Bacteria-Derived Tryosine Decarboxylase APOenzyme

IBCTTYRAPO250MG each
EUR 109
Description: Bacteria-Derived Tryosine Decarboxylase APOenzyme

Presto™ 96 Well gDNA Bacteria Kit (M grade)

96GBB02 each
EUR 275.5

Presto™ 96 Well gDNA Bacteria Kit (M grade)

96GBB04 each
EUR 484

Presto™ 96 Well gDNA Bacteria Kit (M grade)

96GBB10 each
EUR 1080

Bacteria-Derived Tryosine Decarboxylase HOLOenzyme

IBCTTYRHOLO25UN each
EUR 98
Description: Bacteria-Derived Tryosine Decarboxylase HOLOenzyme

MycoLightâ„¢ Live Bacteria Fluorescence Imaging Kit

22409-100Tests 100 Tests
EUR 334
Description: The MycoLight™ Live Bacteria Fluorescence Imaging Kit provides an easy and convenient way for visualizing live bacteria through fluorescent microscope.

AnaPrep Bacterial DNA Extraction Kit (48) For extracting genomic DNA from bacteria

Z1322006 1 kit (48 extractions) Including all required plastic disposables
EUR 259

xTractPure™ Bacteria/Yeast DNA Extraction Kit

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EUR 449

Magnetic Beads-Based Bacteria Genomic DNA Kit

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Magnetic Beads-Based Bacteria Genomic DNA Kit

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Magnetic Beads-Based Bacteria Genomic DNA Kit

abx460017-96tests 96 tests
EUR 437.5

Bacteria-Derived Neuraminidase Purified Lyophilized

IBCTNEUPFLY10UN each
EUR 337
Description: Bacteria-Derived Neuraminidase Purified Lyophilized

Bacteria-Derived Neuraminidase Purified Lyophilized

IBCTNEUPFLY25UN each
EUR 697
Description: Bacteria-Derived Neuraminidase Purified Lyophilized

Bacteria-Derived Neuraminidase Purified Lyophilized

IBCTNEUPFLY5UN each
EUR 174
Description: Bacteria-Derived Neuraminidase Purified Lyophilized

Presto™ gDNA Bacteria Advanced Kit (M-Grade)

GBBA004 each
EUR 5.5

Presto™ gDNA Bacteria Advanced Kit (M-Grade)

GBBA100 each
EUR 165

Presto™ gDNA Bacteria Advanced Kit (M-Grade)

GBBA300 each
EUR 475

Necrotizing hepatopancreatitis bacteria RT PCR kit

RTq-V281-100D 100T
EUR 860.4

Necrotizing hepatopancreatitis bacteria RT PCR kit

RTq-V281-150D 150T
EUR 969.6

Necrotizing hepatopancreatitis bacteria RT PCR kit

RTq-V281-50D 50T
EUR 717.6

Bacteria Borrelia burgdorferi (B. burgdorferi) Protein

abx670009-1mg 1 mg
EUR 510

Bacteria Mycoplasma pneumoniae (M. pneumoniae) Protein

abx670063-1ml 1 ml
EUR 594

MycoLightâ„¢ Flow Cytometric Live Bacteria Assay Kit

22407-100Tests 100 Tests
EUR 334
Description: The MycoLight Flow Cytometric Live Bacteria Assay Kit provides an easy and convenient methodfor evaluating bacterial vitality as a function of the intracellular esterase activity.

Bacteria Botulinum Neurotoxin Type B (botB) Protein

20-abx600049
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Bacteria-Derived Animal Free Collagenase Type A

IBCTAFCLSA100MG each
EUR 97
Description: Bacteria-Derived Animal Free Collagenase Type A

Bacteria-Derived Animal Free Collagenase Type A

IBCTAFCLSA1GM each
EUR 412
Description: Bacteria-Derived Animal Free Collagenase Type A

Bacteria-Derived Animal Free Collagenase Type A

IBCTAFCLSA5GM each
EUR 1456
Description: Bacteria-Derived Animal Free Collagenase Type A

Bacteria-Derived Animal Free Collagenase Type B

IBCTAFCLSB100MG each
EUR 97
Description: Bacteria-Derived Animal Free Collagenase Type B

Bacteria-Derived Animal Free Collagenase Type B

IBCTAFCLSB1GM each
EUR 412
Description: Bacteria-Derived Animal Free Collagenase Type B

Bacteria-Derived Animal Free Collagenase Type B

IBCTAFCLSB5GM each
EUR 1456
Description: Bacteria-Derived Animal Free Collagenase Type B

Bacteria-Derived Animal Free Collagenase Type C

IBCTAFCLSC100MG each
EUR 97
Description: Bacteria-Derived Animal Free Collagenase Type C

Bacteria-Derived Animal Free Collagenase Type C

IBCTAFCLSC1GM each
EUR 412
Description: Bacteria-Derived Animal Free Collagenase Type C

Bacteria-Derived Animal Free Collagenase Type C

IBCTAFCLSC5GM each
EUR 1456
Description: Bacteria-Derived Animal Free Collagenase Type C

Bacteria-Derived FTO Recombinant Protein His Tag

IBCTFTORHIS10UG each
EUR 568
Description: Bacteria-Derived FTO Recombinant Protein His Tag

According to the human embryonic stem cell (hESC) charter, iPSC formation was confirmed by comparatively analyzing hESC markers via colony morphology, immunohistochemistry, qRT-PCR, flow cytometry, gene expression profiling of the three germ layers, and karyotyping. Our results demonstrated that iPSCs were similar to hESCs with regard to morphology, proliferation, hESC-specific surface marker expression, and differentiation into the cell types of the three germ layers.

The efficient generation of iPSCs from the renal tubular cells of an AS patient would provide a novel model to investigate the mechanisms underlying AS and to develop new treatments for AS.

Generation of induced pluripotent stem cells from renal tubular cells of a patient with Alport syndrome.
Generation of induced pluripotent stem cells from renal tubular cells of a patient with Alport syndrome.

The regulation of science and the Charter of Rights: would a ban on non-reproductive human cloning unjustifiably violate freedom of expression?

Non-Reproductive Human Cloning (NRHC) allows researchers to develop and clone cells, including non-reproductive cells, and to research the etiology and transmission of disease. The ability to clone specific stem cells may also allow researchers to clone cells with genetic defects and analyze those cells with more precisions. Despite those potential benefits, Parliament has banned such cloning due to a myriad of social and ethical concerns. In May 2002, the Canadian Government introduced Bill C-13 on assisted human reproductive technologies. Bill C-13 deals with both the scientific and the clinical use of human reproductive materials, and it prohibits a number of other activities, including NRHC. Although the Supreme Court of Canada has never ruled on whether scientific experiments area form of expression, academic support exists for this notion. The authors go through the legal analysis that would be required to find that scientific experiments are expression, focusing in part on whether NRHC could be considered violent and thus fall outside the protection of section 2(b). The latter question is complicated by the ongoing policy debate over whether an “embryonic cell” is property of human life. The authors then consider whether a ban on NRHC could be justified under section 1 of the Charter. They conclude that both the breadth of the legislative purpose and the proportionality of the measure are problematic. Proportionality is a specific concern because the ban could be viewed as an outright denial of scientific freedom of expression. Although consistent with current jurisprudence on freedom of expression, this paper runs against the flow of government policy in the areas of regulation and prohibition of non-reproductive human cloning. As there has been no Charter litigation to date on whether scientific research is a form of expression, the authors introduce a new way of looking at the legality of the regulation of new reproductive technologies.

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