stem cell therapy

Optimization of Differentiation of Nonhuman Primate Pluripotent Cells Using a Combinatorial Approach.

Optimization of Differentiation of Nonhuman Primate Pluripotent Cells Using a Combinatorial Approach.

The directed differentiation of pluripotent stem cells to a desired lineage often involves complex and lengthy protocols. In order to study the requirements for differentiation in a systematic way, we present here methodology for an iterative approach using combinations of small molecules and biological factors. The factors are used in a cyclical process in which the best combination …

Optimization of Differentiation of Nonhuman Primate Pluripotent Cells Using a Combinatorial Approach. Read More »

Generation of induced pluripotent stem cells from renal tubular cells of a patient with Alport syndrome.

Generation of induced pluripotent stem cells from renal tubular cells of a patient with Alport syndrome.

Alport syndrome (AS) is a hereditary disease that leads to kidney failure and is caused by mutations in the COL4A3, COL4A4, and COL4A5 genes that lead to the absence of collagen α3α4α5 (IV) networks in the mature kidney glomerular basement membrane. Approximately 80% of AS is X-linked because of mutations in COL4A5, the gene encoding …

Generation of induced pluripotent stem cells from renal tubular cells of a patient with Alport syndrome. Read More »

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